Head of Computational Chemistry

Cambridge, UK

Dunad Therapeutics is a dynamic biopharmaceutical company focused on the development of next-generation
targeted protein degradation therapies. Dunad’s platform enables selective degradation via direct target modification using tuneable mono-valent small molecules, allowing for the development of more drug-like, orally bioavailable,
and CNS-accessible protein degraders.

The Role

Dunad is seeking a highly talented, diversely experienced and motivated Computational Chemist to join the Drug Discovery Team. The role will provide the opportunity to work on an exciting and dynamic range of drug discovery projects; to use computational tools to both select the targets most amenable to the platform and to design the best molecules for target engagement. The successful applicant will be expected to flawlessly apply their hands-on knowledge of computational methods, and work as part of a team in order to maximise results and facilitate the company's expansion. Furthermore, the successful applicant will demonstrate an ability to run and work on multiple projects at any given time and provide guidance for less experienced team members.

 

The successful candidate will play a key strategic role in building the Computational Chemistry function, including selecting software and tools and recruiting outstanding team members to support the expanding portfolio of internal
and partnered projects.

Key Roles & Responsibilities

  • Build and lead the Computational Chemistry function

  • Conduct small molecule drug discovery projects from hit-finding, through lead generation and optimisation, to candidate selection

  • Apply computational tools to scan for targets most amenable to the Duand platform

  • Utilise both in house resources and those of various partner organisations to effectively deliver on both internal and partnered projects

  • Use leadership skills in order to provide clear data analysis, actionable hypotheses and ideas to drive the projects forward

  • Present plans, methods and results to external partners and internal stakeholders.

  • This includes project and senior management

  • Provide support to both the scientific and operational needs of the department, taking on responsibility for new capabilities as required

Qualifications & Experience

  • A Ph.D. degree in the area of computational chemistry, or equivalent industrial experience

  • Multi-year (+10) experience in world class small molecule drug discovery organisation(s)

  • Expertise in structure- and ligand-based drug discovery with a broad focus and understanding of different target classes

  • Previous experience of working with covalently bonded molecules would be an advantage, but is not essential

  • Understanding of physicochemical properties and DMPK and their importance in small molecule drug design

  • Knowledge of cheminformatics methods and databases

  • Experience with molecular dynamics simulation of small molecules and proteins

  • Evidence of agile and flexible working style in a fast-growing biotech company environment, working closely with internal teams and external partners

  • Previous leadership experience, whether in a matrix or direct reporting setting is a requirement.

Personal attributes

Team oriented, goal-driven, organised, highly collaborative, open-minded, data-driven, creative, persistent in the face
of obstacles and uncertainty, flexible, self-aware of strengths and weaknesses, objective in the evaluation of data
and strongly optimistic about overcoming obstacles.

Location

Dunad is headquartered in and will build its Research Hub in Cambridge, UK. For the right candidate, Dunad can offer considerable flexibility, although some time on site will be required.

The recruitment of this key role is being handled exclusively by Coulter Partners (www.coulterpartners.com) and if you would like to apply, or simply find out more about this exciting opportunity, please contact the team at Dunad@coulterpartners.com