Transformational Therapies Targeting Protein Degradation

Pioneering Tuneable Small-Molecule Degradation Platform

Dunad Therapeutics is focusing on the development of next-generation targeted protein degradation therapies. Dunad’s platform enables selective degradation via direct target modification using tuneable mono-valent small molecules, unlocking new target space and allowing for the development of more drug-like, orally bioavailable and CNS-accessible protein degraders.

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Our Science

Dunad’s unique small molecule platform induces targeted degradation of disease-causing proteins via direct modulation of the target protein’s surface topology. The Company’s novel molecular approach, based on mono-valent small molecules, is fully tuneable to be exquisitely selective for the target, and is underpinned by a target-class agnostic mechanism of action that is distinct from traditional mechanisms of targeted protein degradation.

Our Platform

The Company’s drug pipeline is powered by its expanding 4-pillar proprietary platform:

Proprietary
Degradation Technology

Expanding the frontiers of our plug-and-play mono-valent degrader platform

Proprietary Screening Library

Accelerating Hit ID against novel

targets

Proteomics Workflow

Unlocking previously inaccessible degradation targets via global and multi-dimensional profiling of the proteome

Bioinformatics Pipeline

Driving the best drug candidates through the development

Our Pipeline

Dunad is focusing on targets for which degradation is the optimal mechanism of action, and inhibition of the target’s activity alone is insufficient to elicit the maximum therapeutic effect.

While the unique MOA and compositions of our platform are expected to unlock access to the previously undruggable targets, our platform also enables development of orally bioavailable and CNS-accessible degrader therapeutics, together expanding the frontiers of protein degradation space.

Our Team

Dunad is continuing to expand its world-class scientific team with expertise across protein degradation, covalent therapeutics and proteomics, as well as it’s business leadership team.